Cancer and dementia research is combined in a new 'biology-first' approach. [Sponsored by EisaiUS]
For any biomedical scientist, the acid test is whether their laboratory research makes a real difference to people. Will promising anticancer results in models and experiments, for example, become new therapies to extend and save lives?
Eisai calls its new approach Deep Human Biology Learning . It builds on the emerging realization that different diseases can have common roots and causes. Collapse of protein regulation, for example, can trigger many different medical problems, from dementia to cancer. That is, the same process—the accumulation of misfolded and unfolded proteins—triggers different disease pathways depending on the cells in which it occurs.
Under the new DHBL structure, the company now takes what Uenaka calls a “bedside-to-bench” approach. “We have focused on clinical biomarker research by using patient specimens from our clinical trials and have found several hints about what is happening in patients,” he says. “We will make use of this information in our future drug discovery to advance the development of novel treatments.”
Eisai’s enrichment focuses on three areas. The first is the identification of new ways to prevent cancer from developing resistance to existing drugs. The company is working with a selective inhibitor it believes can block a key protein-protein interaction in the signaling pathway called Wnt, which is closely associated with cancer.
Strong connections EPAT is working on a novel ADC to deliver anticancer agents to multiple tumor types. Central to that work are methods the company has developed to link the agent to specific antibodies. Called Residue-Specific Conjugation Technology , the techniques are designed to reduce variability in the manufacturing process and so improve the quality of the therapeutic molecules.
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