Early warning of the future risk of developing leukaemia in older people may be a step closer thanks to a new study.
Early warning of the future risk of developing leukaemia in older people may be a step closer thanks to a new study from Scotland. Monitoring blood cell samples over time to look for mutations could enable earlier detection – and thus earlier intervention – for the condition, with which 28 new patients are diagnosed every day in the UK, more than 40% of whom are aged 75 and over.
"CHIP is driven by somatic mutations in hematopoietic stem and progenitor cells . Because mutations in HSPCs often drive leukaemia, we hypothesised that HSPC fitness substantially contributes to transformation from CHIP to leukaemia." Dr Kristina Kirschner from the Institute of Cancer Sciences at the University of Glasgow, principal investigator and co-lead author, explained: "In this paper we assess fitness effects, or growth speed, of clones carrying mutations associated with clonal haemopoiesis, using mathematical modelling of longitudinal sequencing data."
Asked whether the results might one day translate to a screening test, she told Medscape UK: “In the first instance, we are hoping this could be rolled out to monitor elderly people from age 60 onwards for signs of blood cancer. Our method requires only two time points and is currently good enough to predict time to next clinical appointment in high-risk patients.
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