The discovery has shed light on a complex blood interaction that has likely always been present in humans but was unnoticed until recently
In February, 2021, as health authorities around the globe raced to blunt the COVID-19 pandemic, reports began to emerge of a rare but serious adverse effect associated with one of the first vaccines to reach the public.based pharmaceutical company AstraZeneca, was soon connected to dangerous blood clots in about one in 66,000 recipientsFast forward four years and the vaccine has long since been discontinued, along with one produced by Johnson & Johnson that caused a similar problem.
Although heparin is typically given to prevent clotting, it can sometimes cause antibodies to bind to a small protein found in human blood known as platelet factor . The antibodies can attach to more than one PF4 protein at time, tangling up into larger complexes that can then turn into blood clots. The condition, called HITT for heparin-induced thrombocytopenia and thrombosis, is uncommon but well-documented in medical literature.
That remains an open question. What Dr. Warkentin said he didn’t expect was to see cases that looked like VITT but in which the blood clots occurred without a virus or a vaccine acting as a trigger. Instead, those cases arose on their own. technologist Jo-Ann Sheppard to devise a test to distinguish samples of HITT from VITT. Sure enough, the case Dr. Warkentin learned about after the seminar was more like VITT.
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