Women have several choices for birth control, but that is not the case for men. However, those options could be expanding.
On Wednesday, scientists reported that a non-hormonal male contraceptive effectively prevented pregnancy in mice without apparent side effects in aAccording to the researchers, most compounds currently undergoing clinical trials target the male sex hormone testosterone, which could lead to side effects such as weight gain, depression and increased cholesterol levels.
To develop their non-hormonal male contraceptive, researchers said they targeted a protein called the retinoic acid receptor alpha. Knocking out the RAR-α gene in male mice made them sterile, without any noticeable side effects. Male mice were also able to reproduce within four to six weeks after they stopped receiving the compound.
The scientists noted that it could be challenging to predict if a compound that looks good in animal studies will also pan out in human trials. So, Georg said the team is also currently exploring other compounds.
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