Big week ahead for 49ers, other favourites

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Big week ahead for 49ers, other favourites
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Massive point spreads on the books as NFL powerhouses look for lopsided wins in Week 3

Fourteen NFL teams are 1-1 and Pro Picks also has an even record through two weeks.The San Francisco 49ers didn’t need much time picking up where they left off. The Niners opened with a pair of road wins and now have won 12 straight regular-season games. Their only loss in the past 15 games was in the NFC championship when they lost both quarterbacks to injury.

After being outscored 60-0 in the first 90 minutes of the season, the Giants rallied from a 21-point deficit to beat Arizona last week.

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