Astros vs Cubs Prediction, Picks, and Odds for Tonight’s MLB Game

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Astros vs Cubs Prediction, Picks, and Odds for Tonight’s MLB Game
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MLB predictions, picks, and odds for Houston Astros at Chicago Cubs on 4-23. MLB best bets and free picks.

With two struggling starters taking the bump in tonight's series opener at Wrigley, Rohit Ponnaiya expects the offenses to show out in this interleague showdown. Read more in our Astros vs. Cubs betting picks.

Despite the Astros' slow start, MLB odds have them installed as slim -115 road favorites for this interleague clash, with the O/U listed at 10.5., who has a 7.08 ERA with an OBA of .295 through four starts. Things don't get any batter behind France, with Houston's relievers pitching to a collective 5.36 ERA and the second-worst OBA in the majors. , who has a 5.29 ERA with an OBA of .284 in four starts. This is an Astros lineup that has historically mashed against lefties like Wicks.

The Cubs are fifth in barrel rate and eighth in hard-hit rate. They are also sixth in runs per game , with that number ticking up to 6.20 at home. Don't overthink this one and fade both of these starters by taking the Over tonight.went hitless in his last game, he's still been red-hot, batting .364 with five multi-hit games in his last nine contests. Busch leads the Cubs with a batting average of .309 and looks likely to pick up a hit tonight against Houston's struggling pitchers.

The Astros were shutout in their last game, and they are 1-5 in their last six contests while plating just 2.67 runs/game during that span.

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