AstraZeneca’s coronavirus antibody treatment failed in late-stage clinical trials to achieve its primary goal of preventing symptomatic Covid-19 in people recently exposed to the virus
by AstraZeneca and the U.S. of using the drug to treat individuals infected with Covid-19. The drugmaker had received support from the U.S. government potentially exceeding $700 million to develop the treatment and, if successful, to supply hundreds of thousands of doses.
But the results did show potential promise in helping reduce the chances of illness from potential infection in the first place. In a parallel analysis of the same AZD7442 phase-three trial data, the antibody combination showed to be 73% effective in reducing the risk of symptomatic Covid-19 in people who tested negative for evidence of the virus at the time they were dosed with the drug.
AstraZeneca said it is continuing to study potential uses for AZD7442 in preventing symptomatic Covid-19. The drug was well-tolerated, with adverse events comparable in the treatment and placebo groups. Of the 1,121 trial participants—all 18 or older and unvaccinated—two-thirds received AZD7442. Of those, 23 developed symptomatic Covid-19, compared with 17 cases in the smaller placebo group.
The success of Covid-19 vaccines, invented and tested at unusually fast speed, has outpaced the development of effective treatments for people after infection, with
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