Engineers load polymer-encased mRNA molecules into turtle-shell pills which, when swallowed, are designed to inject patients from the inside
Two of the most successful covid-19 vaccines, from Pfizer-BioNTech and Moderna, need to be administered via injections because their active ingredients are fragile molecules of mwould be quickly destroyed by acids in the stomach.
This is not new ground for the researchers. Several years ago they collaborated to create a star-shaped structure that could be folded up inside a capsule and then released when the capsule dissolved in the stomach. Once free, the structure remained in the stomach for a month, slowly releasing contraceptives, malaria drugs orWith this in mind, Dr Langer and Dr Traverso wondered whether they could design something that could linger in the stomach and then inject its medication there.
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