It contains artificially engineered human cells.
"These cells required complex electronics and wireless power to control the device," added Fussenegger.
It also relied on an external power supply to"electrically stimulate" the implanted therapeutic cells. By contrast, the push-button does not require any electronics."Energy required for electrostimulation of the cells is simply produced by pushing the button," said Fussenegger.Pushing the piezo film of the devices with a finger produces a"very small" alternating current that stimulates human cells to secrete insulin.
"To become electrosensitive, the cells have been engineered with two specific ion channels that trigger the depolarization of the cell membrane when sensing electrical fields. When depolarized, these cells release insulin in the same way native beta cells do," explains Fussenegger. The technology is highly mature, Fussenegger says. As a result, the team doesn't foresee any obstacles associated with piezo elements. Since "remain more on the cellular part where the longevity of implanted cells needs to be tested for a longer period of time," he added.The team will collaborate with the industry or find a start-up company to develop the technology for the clinics. Fussenegger adds that cell-based therapies typically require roughly 10 years to enter the market.
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