CRISPR may be in for a fight thanks to this new, faster, safer, AI-powered zinc-finger gene-editing technique.
is one such method that can alter and regulate genes. Zinc fingers are one of the most common types of protein structures in the body. They can guide DNA repair by grabbing enzymes that look like scissors and telling them to cut out the wrong parts of the code.
They are found in various proteins, including transcription factors, DNA-binding proteins, and enzymes. They are essential to many biological processes, such as repairing DNA, controlling how genes work, and interacting with other proteins. “Our program can identify the right grouping of zinc fingers for any modification, making this type of gene editing faster than ever before,” says study lead author David Ichikawa, Ph.D., a graduate student at NYU Langone Health., a key gene-editing technology that can be used to find new ways to kill cancer cells and make crops with more nutrients.
“By speeding up zinc-finger design coupled with their smaller size, our system paves the way for using these proteins to control multiple genes [simultaneously],” says senior study author Marcus Noyes, Ph.D., an assistant professor in the Department of Biochemistry and Molecular Pharmacology at NYU Langone.
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