Miniaturized lab-on-a-chip for real-time chemical analysis of liquids tuvienna NatureComms
In the next step, realizing an on-chip QCLD-sensor for similar reaction monitoring experiments, as previously performed in DO, but operating in a highly-absorbing matrix like water, requires a re-designed device geometry. Much shorter plasmonic interaction lengths, typically in the order of 10–15 μm are needed in such a case and are part of our future work.
In a protein denaturation measurement we reveal the typical sigmoidal s-shaped increase of absorbance with increasing BSA treatment temperature, together with a concentration-dependent transition temperature. The latter could be shown by performing dynamic denaturation measurements at concentrations of 20, 40, and 60 mg mlO, was modeled through FEM-based simulations of the plasmonic interaction section including the analyte.
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