A recent study indicates the prevalence of brain changes from limbic-predominant age-related TDP-43 encephalopathy might be approximately 40% in older adults and as high as 50% in people with Alzheimer’s disease According to the researchers, the paper, which will soon be published in Acta Neuropa
The symptoms of Limbic-predominant age-related TDP-43 encephalopathy are comparable to those of Alzheimer’s disease, involving memory loss and issues with thinking and reasoning in old age.
“This is a fundamental question about any disease or condition, ‘How commonly is it seen in peoples’ brains?’ and it is deceptively challenging to answer that question,” said Pete Nelson, M.D., Ph.D., a neuropathologist and the R.C. Durr Foundation Chair in Alzheimer’s Disease at theNelson and a broad group of international scientists collaborated in 2019 to name this new kind of dementia limbic-predominant age-related TDP-43 encephalopathy .
Memory loss and issues with thinking and reasoning are signs of LATE, whose symptoms mimic Alzheimer’s disease. However, researchers discovered that the LATE-affected brain differs from the Alzheimer’s brain in appearance, and treatments that may be helpful for one are likely ineffective for the other.-funded Alzheimer’s Disease Research Centers were represented, including the University of Kentucky, and operated as a large cohesive team.
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